Jason Paul Chua, MD, PhDMedical Reviewer
Jason Chua, MD, PhD, is an assistant professor in the Department of Neurology and Division of Movement Disorders at Johns Hopkins. He received his training at the University of Michigan, where he obtained medical and graduate degrees, then completed a residency in neurology and a combined clinical/research fellowship in movement disorders and neurodegeneration.
Dr. Chua’s primary research interests are in neurodegenerative disease, with a special focus on the cellular housekeeping pathway of autophagy and its impact on disease development in diseases such as amyotrophic lateral sclerosis...
Board Certifications and TrainingAmerican Board of Psychiatry and Neurology, 2019
- Bachelor of Arts in Classics (Latin and Greek) and Biology, Brown University, 2006
- Doctor of Medicine in Neuroscience, University of Michigan Medical School, 2015
- Doctor of Philosophy in Neuroscience, University of Michigan Medical School, 2015
Awards and Accreditation
- Castle Connolly Rising Star
- Keystone Symposium Scholarship, Autophagy: Mechanisms and Disease Conference, National Cancer Institute, 2020
- Best Research Fellow Poster, Neuroscience Day Research Symposium, Department of Neurology, University of Michigan, 2020
- Best Platform Presentation, Neuroscience Day Research Symposium, 2019
- Status Pedagogicus in Situ Award for Excellence in Education/Mentorship of Junior Residents, 2019
- Learning Environment Task Force Recognition of Excellence for Medical Student Teaching, University of Michigan Medical School, 2019
- Bronze Beeper Award for outstanding resident teachers, Galens Medical Society, University of Michigan Medical School, 2019
- Graduation with Distinction in Research, University of Michigan Medical School, 2015
- American Academy of Neurology
- International Parkinson and Movement Disorders Society
- Society for Neuroscience
- American Physician Scientist Association
Chua J, Nafziger E, Leung D. Evidence-Based Practice: Temozolomide Beyond Glioblastoma. (2019)?Current Oncology?Reports?21:30.
Chua JP, Sampath Y, Andress M, Dorey-Stein C. Chapters 9, 42, 79, 94, 122, 129, 145, 167, 183.?The Little Black Book of Neurology?(6th?ed.) Eds. Osama O. Zaidat and Alan J. Lerner. Elsevier, 2019.
Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. (2014)?Human Molecular Genetics?23:1376-86.
Chua JP, Bedi K, Paulsen MT, Ljungman M, Tank EMH, Kim ES, Colon-Mercado JM, Ward ME, Weisman LS, Barmada SJ. Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons. (2021)?bioRxiv?2021.07.20.453106
Chua JP, de Calbiac H, Kabashi E, Barmada SJ. Autophagy and ALS: Mechanistic insights and therapeutic implications. (2021)?Autophagy?2021:1-29
Chua JP, Reddy SL, Yu Z, Giorgetti E, Montie HL, Mukherjee S, Higgins J, McEachin RC, Robins DM, Merry DE, Iniguez-Llhui JA, Lieberman AP. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease. (2015)?J Clin Invest?125:831-45
Grantmanship (successfully funded grant applications):
American Academy of Neurology Career Development Award, 07/01/2021-06/30/2024,?Harnessing neuronal autophagy to rescue a-synuclein-related proteotoxicity in Parkinson disease.?Role: Principal Investigator
Don’t Forget Morgan Foundation Grant, Grant No. G024894, 07/01/2020-06/30/2023,?Defining the neuron-specific mechanisms of autophagy dysfunction and cellular toxicity in β-propeller protein- associated neurodegeneration.?Role: Principal Investigator
NINDS R25 Research Education Grant, R25-NS089450-07, 01/01/2019-12/31/2020,?Characterizing the molecular and cell-specific determinants of neuronal autophagy.?Role: Co-investigator